Institute of Biomedical Chemistry N. Orezhovich. Institute of Biomedical Chemistry named after V.N. Orekhovich RAMN

The Institute was established in 1944 on the basis of the Departments of Biochemistry and Organic Chemistry of VIEM. The first director of the Institute in 1944-1948. was Academician Yakub Oskarovich Parnas. Academician Vasily Nikolaevich Orekhovich headed the Institute in 1949-1989. The recognition of his merits in the development of the Institute was the assignment in 1999 to the Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences named after V.N. Orekhovich. Since 1989, the Institute has been headed by Academician Alexander Ivanovich Archakov.
The largest scientists-biochemists of the country took part in the organization and formation of the Institute: academicians A.E. Braunstein, M.M. Shemyakin, S.E. Severin, V.M. Rodionov, N.A. Yudaev, S.R. Mardashov, T.T. Berezov; corresponding members V.Z. Gorkin, B.F. Korovkin and I.I. Votrin; Professor S.Ya. Kaplansky, G.L. Rosenfeld, G.Ya. Wiederschein, V.S. Tongur, T.S. Easter, and others. Many significant achievements of domestic biomedical science are associated with their names. In particular, A.E. Braunstein obtained fundamental data on the processes of enzymatic transamination and, in collaboration with Academician M.M. Shemyakin, created a general theory of pyridoxal phosphate-dependent reactions; V.N. Orekhovich et al. prolyl endopeptidase (EF 3.4.22.18), cathepsin R (EC 3.4.99.33), and dipeptidylcarboxypeptidase (angiotensin-converting enzyme, EC 3.4.15.1) were discovered and characterized; prof. I.S. Severina obtained fundamental results on deciphering the mechanism of regulation of the activity of aspartate transaminase, the most important enzyme of nitrogen metabolism.
A.I. Archakov is one of the world's leading experts in the field of microsomal oxidation. His work has made a significant contribution to the deciphering of the structural and functional relationships of membrane proteins of the cytochrome P450 superfamily and to understanding the general mechanisms of intermolecular recognition. The results of scientific research obtained by A.A. Archakov et al., were awarded State Prizes: the USSR, the RSFSR and the Russian Federation.
As of January 1, 2004, the Institute employs 210 people, including 122 researchers, including 3 academicians of the Russian Academy of Medical Sciences, 7 professors, 26 doctors and 66 candidates of sciences.
The structure of the Institute includes a department of proteomic research, nine scientific laboratories, an academic group of Academician of the Russian Academy of Medical Sciences T.T. Berezov, research and production department and consultative and diagnostic clinic.
The Institute occupies a leading position in the country in such modern areas of biomedical research as:
- proteomics;
- bioinformatics;
- Nanobiotechnology.
Research and development is carried out by the Institute within the framework of projects of the International Science Foundations (ISTC, INTAS, CRDF, Wellcome Trust, Janssen Research Foundation, Royal Society, etc.), the Russian Foundation for Basic Research, the Russian Academy of Medical Sciences, the Ministry of Health of the Russian Federation, the Ministry of Industry, Science and Technologies of the Russian Federation, the Moscow Committee for Science and Technology, as well as agreements and cooperation agreements with various organizations.
In 2001, on the basis of the Institute, the first in Russia Center for Proteomic Research was established, which operates within the framework of the Interdepartmental Scientific and Technical Program "Proteomics for Medicine and Biotechnology", and a number of projects supported by the Ministry of Industry and Science of the Russian Federation, the Ministry of Health of Russia and the Russian Academy of Medical Sciences. Proteomic studies are associated with the inventory and study of post-translational modifications of proteins using the combined use of methods: two-dimensional electrophoresis, chromatography, mass spectrometric analysis of proteolytic fragments of proteins. Applied research is aimed at developing methods for diagnosing hepatitis and tumors, studying industrially significant microorganisms, etc.
Using 2D-PAGE, MALDI-TOF mass spectrometry and separation on a SELDI chromatographic chip, it was found that haptoglobin alpha chain, apolipoprotein A-I, A-IV, orosomucoid are statistically significant markers of ovarian cancer, and sulfated glycoprotein is a marker of breast cancer. Methods for the analysis of membrane proteins developed in the department made it possible to obtain a proteomic map of liver microsomal proteins reflecting changes in protein expression during their drug induction. In order to study the variability of Helicobacter pylori strains, proteomic typing of isolates from different regions of Russia was carried out.
The staff of the proteomic department developed computer programs and databases for analyzing complex mass spectra and for identifying marker proteins on proteomic maps, as well as an educational program for the proteomics course to improve the skills of researchers working in the field of biochemistry and molecular biology.
Works in the field of bioinformatics are aimed at creating an integral platform covering the entire chain of research “from genomes to drugs in silico”, which solves the following tasks: (1) identification of target macromolecules based on genomic and proteomic data; (2) validation of the found targets by computer and experimental methods; (3) identifying the most promising basic structures of new drugs; (4) optimization of basic drug structures. The basic structures of new drugs identified using bioinformatics methods are being tested in experiments in vitro and in vivo. The practical result of these studies was: the identification of the most promising targets for the creation of drugs against Mycobacterium Tuberculosis; selection of immunogenic peptides in the polyprotein of the hepatitis C virus for the creation of vaccine constructs; construction of new highly selective monoamine oxidase A inhibitors as potential antidepressants; the discovery of original anxiolytics and nootropics with a high degree of novelty of the chemical structure, the identification of antihypertensive substances with combined mechanisms of action, etc. The Institute develops nanobiotechnological approaches that have several orders of magnitude higher sensitivity and speed compared to currently used standard methods of analysis. These include methods based on the use of optical nanostructured biosensors coupled with mass spectrometers, atomic force microscopes, which make it possible to detect, concentrate and identify functionally significant biomacromolecules in biological fluids in a wide range of concentrations (from micro- to attomoles).
Every year, the staff of the Institute publishes 50-80 scientific articles in domestic and international scientific journals; Over the past decade, 19 Russian and 2 international patents have been received.
A new drug for the treatment of chronic liver diseases of various etiology PHOSPHOGLIV (capsule and injection forms) has been developed and introduced into medical practice. In order to organize the production of this drug at the Institute, the building was reconstructed and a production site was organized.
On the basis of the Institute, the Scientific Council of the Russian Academy of Medical Sciences and the Ministry of Health of the Russian Federation operates on biomedical chemistry, in which 11 research organizations take part.
The Institute has a system of personnel training through competition and postgraduate study in the specialty "biochemistry"; there is a dissertation council for the defense of dissertations for the degree of doctor and candidate of biological and medical sciences in the specialty "biochemistry". Over the past decade, 8 doctoral and 52 master's theses have been defended.
The Institute is an educational and research base for students, graduate students and graduate students from the IBF RSMU, MMA named after. THEM. Sechenov, MEPhI, Moscow Institute of Physics and Technology and other universities in Moscow, which carry out term papers, theses and dissertations here using postgenomic technologies. Employees of the Institute take part in lecturing and holding seminars for students of the ICF RSMU, MGSA and MAPO.
The Institute publishes the scientific journal "Biomedical Chemistry" (ISSN 0042-8809), which publishes works on all modern sections of biological and medicinal chemistry.
In recent years, the scientific achievements of the State Research Institute of Biochemical Chemistry of the Russian Academy of Medical Sciences have been awarded a number of awards: the State Prize of the Russian Federation in the field of science and technology for 1998 for the work "Microsomal oxidation and drug metabolism: the mechanism of oxygenase reactions catalyzed by cytochrome P450 and their modeling", Prize of the Government of the Russian Federation in the field of science and technology for 2002 for the creation of a domestic drug for the treatment of liver diseases "Phosphogliv", two Prizes of the Presidium of the Russian Academy of Medical Sciences for the results obtained in the field of fundamental medical research.
Preserving the traditions of the national scientific school, laid down by the academicians of the Russian Academy of Medical Sciences Ya.O. Parnassus, V.N. Orekhovich, A.I. Archakov, and developing international scientific cooperation, the Institute is today one of the leading centers of biomedical science in Russia.

Biomedical research is carried out at IBMC in the following areas:

• Identification of biomarkers for risk prediction and early diagnosis of socially significant diseases using postgenomic technologies (personalized medicine)
• Development of molecular detectors, reagents, algorithms and laboratory protocols for creating new methods of medical diagnostics
• Search for molecular targets, design and study of physiologically active substances, creation of drug transport systems

Department of Bioinformatics:

The Bioinformatics Department of IBMC conducts research in the field of bioinformatics and computer-aided drug design. Availability of qualified specialists, original and commercially available software and databases, as well as high-performance computing resources allows for fundamental research and applied development, covering the entire chain "From genomes to drugs in silico".

The Bioinformatics Department of IBMC currently includes five laboratories:

Bioinformation Technologies (Head - Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences Andrey V. Lisitsa).

Analysis of postgenomic data (supervisor - Ph.D. Elena Aleksandrovna Ponomarenko).

Structural-functional design of drugs (supervisor - Prof., Doctor of Biological Sciences, Ph.D. Vladimir Vasilyevich Poroikov).

Structural Bioinformatics (Head - Doctor of Biological Sciences Alexander Vladimirovich Veselovsky).

Parallel Computing and Information Technologies (supervisor - Ph.D. Vladlen Stanislavovich Skvortsov).

From Wikipedia, the free encyclopedia

Institute of Biomedical Chemistry named after V. N. Orekhovich RAMS (IBMCh RAS)
Based
Director	Andrey Valerievich Lisitsa
Employees	270 people, including 178 scientists
PhD
Location
Legal address	History At various times, scientists-biochemists academicians A. E. Braunshtein, M. M. Shemyakin, S. E. Severin, N. A. Yudaev, S. R. Mardashev, T. T. Berezov worked at the institute; corresponding members V. Z. Gorkin, B. F. Korovkin and I. I. Votrin; professors S. Ya. Kaplansky, G. L. Rosenfeld, G. Ya. Widershain, V. S. Tongur, T. S. Paskhina. Research area proteomics; Proteomic studies are associated with the study of post-translational modifications of proteins. bioinformatics; Bioinformatics covers research from genomes to drugs and solves the following problems: identification of target macromolecules based on genomic and data; synthesis of new drugs. nanobiotechnology. Nanobiotechnologies use nanostructured biosensors that make it possible to determine functionally significant biomacromolecules in biological fluids. The Institute has developed Phosphogliv, a drug intended for the treatment of chronic liver diseases. Institute structure The institute includes departments of proteomic research and mass spectrometry, personalized medicine, nanodrugs, bioinformatics, scientific laboratories for protein biosynthesis, peptide engineering, microsomal oxidation, etc. Modernity Currently, the institute is working in the following areas: the use of biomarkers for the early diagnosis of diseases, the development of molecular detectors, reagents for new methods of diagnosing diseases, the creation of drug transport systems in the human body. Proceedings The scientific works of the Institute staff are published in the journal "Biomedical Chemistry" published by the Institute (until 2003 - "Issues of Medical Chemistry"). Write a review on the article "V. N. Orekhovich Institute of Biomedical Chemistry" Links Notes Coordinates : 55°43′57″ s. sh. 37°34′03″ W d. /  55.73250° N sh. 37.56750° W d./ 55.73250; -37.56750(G) (I) An excerpt characterizing the Institute of Biomedical Chemistry named after V. N. Orekhovich “I’m listening, Your Excellency,” Timokhin said, with a smile making it feel that he understood the wishes of the boss. - Yes Yes. The regimental commander found Dolokhov in the ranks and reined in his horse. “Before the first case, epaulettes,” he told him. Dolokhov looked around, said nothing and did not change the expression of his mockingly smiling mouth. “Well, that’s good,” continued the regimental commander. “People get a glass of vodka from me,” he added, so that the soldiers could hear. – Thank you all! Thank God! - And he, having overtaken a company, drove up to another. “Well, he really is a good man; You can serve with him,” Timokhin subaltern said to the officer walking beside him. - One word, red! ... (the regimental commander was nicknamed the red king) - the subaltern officer said, laughing. The happy mood of the authorities after the review passed to the soldiers. Rota was having fun. Soldiers' voices were talking from all sides. - How did they say, Kutuzov crooked, about one eye? - But no! Totally crooked. - Not ... brother, more big-eyed than you. Boots and collars - looked around everything ... - How does he, my brother, look at my feet ... well! think… - And the other is an Austrian, he was with him, as if smeared with chalk. Like flour, white. I'm tea, how they clean ammunition! - What, Fedeshow! ... he said, perhaps, when the guards begin, did you stand closer? They said everything, Bunaparte himself is standing in Brunov. - Bunaparte stands! you lie, fool! What does not know! Now the Prussian is in revolt. The Austrian, therefore, pacifies him. As soon as he reconciles, then war will open with Bounaparte. And then, he says, in Brunov, Bunaparte is standing! It's obvious that he's an idiot. You listen more. “Look, damn tenants! The fifth company, look, is already turning into the village, they will cook porridge, and we will not reach the place yet. - Give me a cracker, damn it. “Did you give tobacco yesterday?” That's it, brother. Well, on, God is with you. - If only they made a halt, otherwise you won’t eat another five miles of proprem. - It was nice how the Germans gave us strollers. You go, know: it's important! - And here, brother, the people went completely frantic. There everything seemed to be a Pole, everything was of the Russian crown; and now, brother, a solid German has gone. - Songwriters ahead! - I heard the cry of the captain. And twenty people ran out in front of the company from different ranks. The drummer sings turned around to face the song-books, and, waving his hand, sang a drawn-out soldier's song, beginning: "Isn't it dawn, the sun was breaking up ..." and ending with the words: "That, brothers, will be glory to us with Kamensky father ..." This song was composed in Turkey and was now sung in Austria, only with the change that in place of "Kamensky father" the words were inserted: "Kutuzov's father." Tearing off these last words like a soldier and waving his arms as if he was throwing something on the ground, the drummer, a dry and handsome soldier of about forty, sternly looked around at the songwriter soldiers and closed his eyes. Then, making sure that all eyes were fixed on him, he seemed to carefully lift with both hands some invisible, precious thing above his head, held it like that for several seconds, and suddenly threw it desperately: Oh, you, my canopy, my canopy! “Canopy my new…”, twenty voices picked up, and the spoonman, despite the heaviness of ammunition, briskly jumped forward and walked backwards in front of the company, moving his shoulders and threatening someone with spoons. The soldiers, swinging their arms to the beat of the song, walked with a spacious step, involuntarily hitting the leg. Behind the company came the sounds of wheels, the crunch of springs and the clatter of horses. Kutuzov with his retinue was returning to the city. The commander-in-chief signaled that the people should continue to walk freely, and his face and all the faces of his retinue expressed pleasure at the sound of the song, at the sight of the dancing soldier and the merrily and briskly marching soldiers of the company. In the second row, from the right flank, from which the carriage overtook the companies, a blue-eyed soldier, Dolokhov, involuntarily caught the eye, who walked especially briskly and gracefully to the beat of the song and looked at the faces of the passers-by with such an expression as if he pitied everyone who did not go at this time with a company. A hussar cornet from Kutuzov's retinue, mimicking the regimental commander, lagged behind the carriage and drove up to Dolokhov.

Information taken from open sources. If you want to become a page moderator
.

Chemical technology and biotechnology, Chemistry

Directions:

Full-time, Part-time, Part-time

Form of study:

No. 0004 series 90L01 No. 0000004 valid from 05/29/2012 indefinitely

Licenses:

state sample

Completion document:

Teaching language:

Department of Proteomic Research and Mass Spectrometry, Department of Bioinformatics, Department of Personalized Medicine, Scientific Laboratories, Department of Nanodrugs

Divisions:

University characteristics

Availability of a departmental school for the children of employees:
Presence of a departmental kindergarten for the children of employees:
Educational activities:
Educational programs - OP:
Dissertation Council:
Scientific publications:
Subsidiaries, representative offices, branches:
Production base:
Advanced training programs:
Availability of HAC media:

general information

FGBU "IBMH" RAMS conducts biomedical research in the following areas:
Identification of biomarkers for risk prediction and early diagnosis of socially significant diseases using postgenomic technologies (personalized medicine)
Development of molecular detectors, reagents, algorithms and laboratory protocols for creating new methods of medical diagnostics
Search for molecular targets, design and study of physiologically active substances, creation of drug transport systems

The staff number is 182 employees, of which 169 are scientific employees (doctors of sciences - 29, candidates of sciences - 82).

The Institute's cumulative h-index for 2011 according to Web of Science is 32.

Areas of expertise: biochemistry and medicinal chemistry, transcriptomics, proteomics and metabolomics, nanobiotechnology, cell and systems biology, bioinformatics.

The Institute is an educational and research base for students of the Faculty of Medicine and Biology of the Russian National Research Medical University.

Established in 1944 as the Institute of Biological and Medical Chemistry of the USSR Academy of Medical Sciences on the basis of the Departments of Biochemistry and Organic Chemistry of the All-Union Institute of Experimental Medicine.

The modern name is from 1992. In 1944-1948. The Institute was headed by Acad. AN SSR Ya.O. Parnassus, in 1949-1989 - acad. RAMS V.N. Orekhovich. Acad. A.E. Braunstein, M.M. Shemyakin, S.E. Severin, N.A. Yudaev and other outstanding Russian biochemists.

The main research is related to the study of the structural and functional organization of biological macromolecules, the mechanisms of intermolecular recognition during immune reactions, enzyme-substrate interactions, in the processes of reception, the development of new methods of bioinformatics and computer design of drugs, the creation of tools for the diagnosis and treatment of the most common diseases; hepatoprotector "Phosphogliv" has been developed and is being produced for the treatment of liver diseases of various etiologies, including viral hepatitis (award of the Government of the Russian Federation in the field of science and technology (2003) for the creation of the domestic drug "Phosphogliv" for the treatment of liver diseases).

The Institute established the country's first Department of Proteomic Research (2000) and the Center for Collective Use "Human Proteome" (from 2003 to 2010 the Center for Collective Use "Center for Post-Genomic Technologies"), the scientific and practical journal "Biomedical Chemistry" is published (name until 2003 - "Issues of medical chemistry"). Since 2007, the most rated articles of the journal "Biomedical Chemistry" have been published in English as a supplement to the journal Biochemistry (Moscow) - Supplement Series B: Biomedical Chemistry.

The Institute is an educational and research base for undergraduate and graduate students.

1 of

Fundamental scientific research programs of the Russian Academy of Medical Sciences for 2008-2012:
Study of the molecular mechanisms of the development of socially significant diseases using postgenomic technologies. (lab. diagnostic proteomics)
Development of a systematic approach to the analysis of living objects by combining the methods of genomics, transcriptomics, metabolomics and bio- and chemoinformatics with mathematical data processing tools in order to identify molecular targets for drug action. (Lab. of Systems Biology and Structural-Functional Design of Drugs)
Development of original algorithms and computer programs for establishing relationships "amino acid sequence - structure - function" and predicting the functions of new proteins based on amino acid sequences. (Lab. Bioinformation Technologies)
Development of fundamental and applied problems of nanopathology. (lab. nanobiotechnology)
Search for new molecular targets for the pharmacological regulation of pathological processes in diseases of the central nervous system and the cardiovascular system (laboratory of biochemistry of amines and cyclic nucleotides)
Development of experimental and computational approaches for the rational design of drugs and the creation of drug nanocomposites and nanodrugs (Lab. Phospholipid Nanodrugs and Transport Systems)
Study of molecular genetic and biochemical mechanisms of neoplastic transformation and tumor progression, new molecular markers for diagnostics (lab. of amine biosynthesis)
Topics of the IBMC RAMS within the framework of the RAMS program "Nanotechnologies and nanomaterials in medicine for the period 2008-2015":
Development of technologies for determining ultra-low concentrations of molecules using molecular detectors (Lab. Nanobiotechnology)
Development of medical diagnostic systems based on atomic force microscopy and nanoconductive materials (nanobiotechnology laboratory)
Study of new drugs equipped with a transport system based on phospholipid nanoparticles (lab. of phospholipid nanodrugs and transport systems)